Analysis of Gene Expression Data Spring Semester , 2007 Lecture 5 : May 24 , 2007
نویسنده
چکیده
As we have seen in previous lectures, the technology of DNA chips allows the measurement of mRNA levels simultaneously for thousands of genes. The abundance of readily available data allows us the option to try to extract information, not easily seen while analyzing a single test, from the results of a multitude of tests. The results of DNA chip experiments are usually organized together in a gene expression matrix, with rows corresponding to genes and columns corresponding to conditions. A bicluster can be defined as a submatrix spanned by a subset of genes and a subset of conditions in which the genes have joint behavior in the corresponding conditions. Different algorithmic approaches to the biclustering problem use different measures for the quality of a given biclustering solution. Hence, the definition of the goal function of each algorithm is part of its description. There are two important themes regarding biclustering algorithms:
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